Sildenafil Citrate – Buy Cheap Viagra Generic Online Without Prescription

Sildenafil Citrate Рpotency regulator, is  a new drug intended for treatment of erectile disorders and insufficiency of genital reaction. It restores broken erectile function and provides natural response to sexual excitation.

Properties / Action: Sildenafil is a new oral drug intended for erectile dysfunction treatment. It restores broken erectile function and provides natural response to sexual excitation. Sexual stimulation is necessary for appearance of favorable pharmacological effect of sildenafil.

The physiological mechanism of penis erection assumes nitrogen oxide (N0) release in cavernous body during sexual stimulation. Nitrogen oxide activates definite enzyme that leads to increase the level of cyclic guanozimnophosphate ,which in turn, results to a relaxation of smooth muscles of cavernous body and to blood inflow for penis strengthening. Sildenafil is powerful and selective inhibitor, which is responsible for specific enzymes disintegration in cavernous body.

Pharmacokinetics

Sildenafil is quickly soaked up. Concentration of the drug in plasma after its intake on an empty stomach reaches its peak within 30-120 minutes Absolute bioavailability is on the average 25-63%. Speed of soaking up of sildenafil decreases if it is taken in combination with fat food. The final period of half-withdraw of  sildenafil is 3-5 hours. After sildenafil intake it is deduced in a kind of metabolites with faeces (approximately 80 % of the entered dose) and to a lesser degree with urine (approximately 13 % of the entered dose).

Healthy elderly volunteers (65 years and more senior) had lower sildenafil clearance, and concentration of free medicinal substance in plasma approximately on 40 % exceeds its level of healthy young volunteers (18-45 years).

Volunteers with easy and moderate nephritic insufficiency the sildenafil pharmacokinetics did not change after unitary intake (50 mg). Volunteers with heavy nephritic insufficiency had sildenafil clearance decreased. Volunteers with a cirrhosis had also sildenafil clearance decreased.